Mastonaut is a really nice macOS client. It’s not free but the author has clearly put in the work to make it nice. https://apps.apple.com/us/app/mastonaut/id1450757574?mt=12
@foozmeat I keep coming back to the web version for both desktop and mobile. It's so good!
@d I do really like the single-column layout now. Sadly I need to keep tabs on several accounts at once so a client is the way to go.